Slate - Death by Spam: The e-mail you know and love is about to vanish.
...sophisticated Internet users are turning to a new approach. Instead of trying to block spam while allowing everything else, these users employ software that blocks everything except messages from already known, accepted senders. These systems, called "whitelists," change e-mail from an open system to a closed one.
I'm getting maybe 30-40 pieces of spam a day on 2 different email accounts. I'm not sure what to do about it because most of the solutions are for Outlook/Exchange and I'm Eudora (client) and QMail (server.)

It's all about SpamAssassin.
I have a yahoo account & 4 pop accounts - one which I still access via telnet, the others I access via Pegasus, Outlook, and Mozilla. 2 are with my ISP, 2 are of my domain.
And I get WELL OVER 50 spam e-mails a day. And that's not even counting the ones that are filtered out in my Yahoo. (By far, I get the least amount of spam in my Yahoo.)
For my 4 pop accounts I use Mailwasher (I think it's mailwasher.com - but I'm not sure.)
Anyway, it checks all e-mail at once, you can blacklist, delete & bounce without downloading to your mail programme. All accounts can be checked at once. It's a nifty kind of small programme you can keep open all the time too.
I believe there is a way to make a "white list" with it as well.